top of page



Yaniv Assaf, PhD

Main inverstigator, List of publications

  • 2020
    Berman, Z., Assaf, Y., Tarrasch, R., & Joel, D. (2020). Macro- and microstructural gray matter alterations in sexually assaulted women. Journal of affective disorders, 262, 196–204. Tavor, I., Botvinik-Nezer, R., Bernstein-Eliav, M., Tsarfaty, G., & Assaf, Y. (2020). Short-term plasticity following motor sequence learning revealed by diffusion magnetic resonance imaging. Human brain mapping, 41(2), 442–452. Assaf, Y., Bouznach, A., Zomet, O., Marom, A., & Yovel, Y. (2020). Conservation of brain connectivity and wiring across the mammalian class. Nature neuroscience, 23(7), 805–808. Abend, R., Rosenfelder, A., Shamai, D., Pine, D. S., Tavor, I., Assaf, Y., & Bar-Haim, Y. (2020). "Does attention bias modification induce structural brain changes? A commentary on Abend et al. (2019)" - Response. Biological psychology, 152, 107865. Shamir, I., Assaf, Y. An MRI-Based, Data-Driven Model of Cortical Laminar Connectivity. Neuroinform (2020). Zur, G., Lesman-Segev, O. H., Schlesinger, I., Goldsher, D., Sinai, A., Zaaroor, M., Assaf, Y., Eran, A., & Kahn, I. (2020). Tremor Relief and Structural Integrity after MRI-guided Focused US Thalamotomy in Tremor Disorders. Radiology, 294(3), 676–685.
  • 2019
    Assaf Y. (2019). Imaging laminar structures in the gray matter with diffusion MRI. NeuroImage, 197, 677–688. Assaf, Y., Johansen-Berg, H., & Thiebaut de Schotten, M. (2019). The role of diffusion MRI in neuroscience. NMR in biomedicine, 32(4), e3762. Abend, R., Rosenfelder, A., Shamai, D., Pine, D. S., Tavor, I., Assaf, Y., & Bar-Haim, Y. (2019). Brain structure changes induced by attention bias modification training. Biological psychology, 146, 107736. Shamir, I., Tomer, O., Baratz, Z., Tsarfaty, G., Faraggi, M., Horowitz, A., & Assaf, Y. (2019). A framework for cortical laminar composition analysis using low-resolution T1 MRI images. Brain structure & function, 224(4), 1457–1467. Lotan E, Tavor I, Barazany D, Ben-Amitay S, Hoffmann C, Tsarfaty G, Assaf Y, Tanne D., (2019). Selective atrophy of the connected deepest cortical layers following small subcortical infarct. Neurology, Jan 2019. 10.1212/WNL.0000000000006884; DOI:10.1212/WNL.0000000000006884
  • 2018
    No publications
  • 2017
    Assaf Y, Johansen-Berg H, Thiebaut de Schotten M. (2017). The role of diffusion MRI in neuroscience. NMR Biomed. Hofstetter, S., & Assaf, Y. (2017). The rapid development of structural plasticity through short water maze training: A DTI study. NeuroImage, 155, 202-208. (Link here) Lifshits, S., Tomer, O., Shamir, I., Barazany, D., Tsarfaty, G., Rosset, S., & Assaf, Y. (2017). Resolution considerations in imaging of the cortical layers. NeuroImage. Hofstetter, S., Friedmann, N., & Assaf, Y. (2017). Rapid language-related plasticity: microstructural changes in the cortex after a short session of new word learning. Brain structure & function, 222(3), 1231-1241.
  • 2016
    De Santis, S., Assaf, Y., Jeurissen, B., Jones, D. K., & Roebroeck, A. (2016). T 1 relaxometry of crossing fibres in the human brain. Neuroimage, 141, 133-142. Amitay, S. B., Lifshits, S., Barazany, D., & Assaf, Y. (2016). 3-dimensional axon diameter estimation of white matter fiber tracts in the human brain.
  • 2015
    Horowitz A, Barazany D, Tavor I, Bernstein M, Yovel G, Assaf Y., In vivo correlation between axon diameter and conduction velocity in the human brain. Ben-Sira L, Goder N, Bassan H, Lifshits S, Assaf Y, Constantini S., Clinical benefits of diffusion tensor imaging in hydrocephalus. Joel D, Berman Z, Tavor I, Wexler N, Gaber O, Stein Y, Shefi N, Pool J, Urchs S, Margulies DS, Liem F, Hänggi J, Jäncke L, Assaf Y., Sex beyond the genitalia: The human brain mosaic.
  • 2014
    Dinai Y, Wolf L, Assaf Y., Combined neuroimaging and gene expression analysis of the genetic basis of brain plasticity indicates across species homology. Kunz N, Zhang H, Vasung L, O'Brien KR, Assaf Y, Lazeyras F, Alexander DC, Hüppi PS., Assessing white matter microstructure of the newborn with multi-shell diffusion MRI and biophysical compartment models. De Santis S, Drakesmith M, Bells S, Assaf Y, Jones DK., Why diffusion tensor MRI does well only some of the time: variance and covariance of white matter tissue microstructure attributes in the living human brain. Tavor I, Yablonski M, Mezer A, Rom S, Assaf Y, Yovel G., Separate parts of occipito-temporal white matter fibers are associated with recognition of faces and places.
  • 2013
    Aharoni R, Sasson E, Blumenfeld-Katzir T, Eilam R, Sela M, Assaf Y, Arnon R., Magnetic resonance imaging characterization of different experimental autoimmune encephalomyelitis models and the therapeutic effect of glatiramer acetate., Exp Neurol. 2013 Feb;240:130-44. Assaf Y, Alexander DC, Jones DK, Bizzi A, Behrens TE, Clark CA, Cohen Y, Dyrby TB, Huppi PS, Knoesche TR, Lebihan D, Parker GJ, Poupon C; CONNECT consortium, Anaby D, Anwander A, Bar L, Barazany D, Blumenfeld-Katzir T, De-Santis S, Duclap D, Figini M, Fischi E, Guevara P, Hubbard P, Hofstetter S, Jbabdi S, Kunz N, Lazeyras F, Lebois A, Liptrot MG, Lundell H, Mangin JF, Dominguez DM, Morozov D, Schreiber J, Seunarine K, Nava S, Poupon C, Riffert T, Sasson E, Schmitt B, Shemesh N, Sotiropoulos SN, Tavor I, Zhang HG, Zhou FL., The CONNECT project: Combining macro- and micro-structure., Neuroimage. 2013 Oct 15;80:273-82. De Santis S, Assaf Y, Evans CJ, Jones DK., Improved precision in CHARMED assessment of white matter through sampling scheme optimization and model parsimony testing., Magn Reson Med. 2013 Mar 8. Hofstetter S, Tavor I, Tzur Moryosef S, Assaf Y., Short-term learning induces white matter plasticity in the fornix., J Neurosci. 2013 Jul 31;33(31):12844-50. Lax E, Friedman A, Croitoru O, Sudai E, Ben-Moshe H, Redlus L, Sasson E, Blumenfeld-Katzir T, Assaf Y, Yadid G., Neurodegeneration of lateral habenula efferent fibers after intermittent cocaine administration: implications for deep brain stimulation., Neuropharmacology. 2013 Dec;75:246-54. Jouroukhin Y, Ostritsky R, Assaf Y, Pelled G, Giladi E, Gozes I., NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: protection against impairments in axonal transport., Neurobiol Dis. 2013 Aug;56:79-94. Kafri M, Sasson E, Assaf Y, Balash Y, Aiznstein O, Hausdorff JM, Giladi N., High-level gait disorder: associations with specific white matter changes observed on advanced diffusion imaging., J Neuroimaging. 2013 Jan;23(1):39-46. Sasson E, Doniger GM, Pasternak O, Tarrasch R, Assaf Y., White matter correlates of cognitive domains in normal aging with diffusion tensor imaging., Front Neurosci. 2013 Mar 13;7:32. Tavor I, Hofstetter S, Assaf Y., Micro-structural assessment of short term plasticity dynamics., Neuroimage. 2013 Nov 1;81:1-7.
  • 2012
    Barazany D, Assaf Y., Visualization of cortical lamination patterns with magnetic resonance imaging., Cereb Cortex. 2012 Sep;22(9):2016-23 Ben-Amitay S, Jones DK, Assaf Y., Motion correction and registration of high b-value diffusion weighted images., Magn Reson Med. 2012 Jun;67(6):1694-702. De Santis S, Assaf Y, Jones DK. Using the biophysical CHARMED model to elucidate the underpinnings of contrast in diffusional kurtosis analysis of diffusion-weighted MRI., MAGMA. 2012 Aug;25(4):267-76 Lifshitz V, Weiss R, Benromano T, Kfir E, Blumenfeld-Katzir T, Tempel-Brami C, Assaf Y, Xia W, Wyss-Coray T, Weiner HL, Frenkel D., Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model., Neurobiol Aging. 2012 Feb;33(2):432.e1-432.e13. Sadan O, Shemesh N, Barzilay R, Dadon-Nahum M, Blumenfeld-Katzir T, Assaf Y, Yeshurun M, Djaldetti R, Cohen Y, Melamed E, Offen D., Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington's disease., Exp Neurol. 2012 Apr;234(2):417-27 Sagi Y, Tavor I, Hofstetter S, Tzur-Moryosef S, Blumenfeld-Katzir T,Assaf Y., Learning in the fast lane: new insights into neuroplasticity., Neuron. 2012 Mar 22;73(6):1195-203. Sasson E, Doniger GM, Pasternak O, Tarrasch R, Assaf Y., Structural correlates of cognitive domains in normal aging with diffusion tensor imaging., Brain Struct Funct. 2012 Apr;217(2):503-15. Shemesh N, Barazany D, Sadan O, Bar L, Zur Y, Barhum Y, Sochen N, Offen D, Assaf Y, Cohen Y., Mapping apparent eccentricity and residual ensemble anisotropy in the gray matter using angular double-pulsed-field-gradient MRI., Magn Reson Med. 2012 Sep;68(3):794-806
  • 2011
    Sadan O, Shemesh N, Barzilay R, Dadon-Nahum M, Blumenfeld-Katzir T, Assaf Y, Yeshurun M, Djaldetti R, Cohen Y, Melamed E, Offen D., Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: A potential therapy for Huntington’s disease. Exp. Neurol.2011. Ben-Amitay S., Jones D., Assaf Y. Motion correction and registration of high b-value diffusion weighted images. Magnetic Resonance in Medicine Shemesh N, Barazany D, Sadan O, Bar L, Zur Y, Barhum Y, Sochen N, Offen D, Assaf Y, Cohen Y. Mapping apparent eccentricity and residual ensemble anisotropy in the gray matter using angular double-pulsed-field-gradient MRI. Magnetic Resonance in Medicine 2011. De Santis S., Assaf Y., Jones D.K. Using the biophysical CHARMED model to elucidate the underpinnings of contrast in diffusional kurtosis analysis of diffusion-weighted MRI. Magnetic Resonance in Medicine 2011. Barazany D., Assaf Y. Visualization of Cortical Lamination Patterns with Magnetic Resonance Imaging. Cerebral Cortex 2011. Sasson E., Doniger G.M., Pasternak O., Tarrasch R., Assaf Y. Structural correlates of cognitive domains in normal aging with diffusion tensor imaging. Brain Struct. Funct. 2011. Blumenfeld-Katzir T, Pasternak O, Dagan M, Assaf Y. Diffusion MRI of structural brain plasticity induced by a learning and memory task. PloS One 2011. Lifshitz V, Weiss R, Benromano T, Kfir E, Blumenfeld-Katzir T, Tempel-Brami C, Assaf Y, Xia W, Wyss-Coray T, Weiner HL, Frenkel D. Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model.Neurobiol Aging 2011.
  • 2010
    Aizman E, Mor A, Chapman J, Assaf Y, Kloog Y. The combined treatment of Copaxone and Salirasib attenuates experimental autoimmune encephalomyelitis (EAE) in mice. J Neuroimmunol 2010; 229(1-2):192-203. Geva M, Cabilly Y, Assaf Y, Mindroul N, Marom L, Raini G, Pinchasi D, Elroy-Stein O. A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter. Brain 2010;133(Pt 8):2448-2461. Levy H, Assaf Y, Frenkel D., Characterization of brain lesions in a mouse model of progressive multiple sclerosis. Exp Neurol 2010;226(1):148-58. Robinson A, Kloog Y, Stein R, Assaf Y., Motor deficits and neurofibromatosis type 1 (NF1)-associated MRI impairments in a mouse model of NF1. NMR Biomed 2010;23(10):1173-80. Sasson E, Doniger GM, Pasternak O, Assaf Y., Structural correlates of memory performance with diffusion tensor imaging. Neuroimage 2010;50(3):1231-1242. Dror V, Eliash S, Rehavi M, Assaf Y, Biton IE, Fattal-Valevski A. Neurodegeneration in thiamine deficient rats-A longitudinal MRI study. Brain Res 2010;1308:176-84.
  • 2009 & Prior
    Piontkewitz Y, Assaf Y, Weiner I., Clozapine Administration in Adolescence Prevents Postpubertal Emergence of Brain Structural Pathology in an Animal Model of Schizophrenia. Biol Psychiatry 2009;66(11):1038-46. Pasternak O, Sochen N, Gur Y, Intrator N, Assaf Y., Free water elimination and mapping from diffusion MRI. Magn Reson Med 2009;62(3):717-730. Freidlin RZ, Ozarslan E, Assaf Y, Komlosh ME, Basser PJ. A multivariate hypothesis testing framework for tissue clustering and classification of DTI data. NMR Biomed 2009;22(7):716-729. Lifshits S, Tamir A, Assaf Y. Combinatorial fiber-tracking of the human brain. Neuroimage 2009;48(3):532-540. Barazany D, Basser PJ, Assaf Y. In vivo measurement of axon diameter distribution in the corpus callosum of rat brain. Brain 2009;132(Pt 5):1210-1220. Baranes K, Raz-Prag D, Nitzan A, Galron R, Ashery-Padan R, Rotenstreich Y, Assaf Y, Shiloh Y, Wang ZQ, Barzilai A, Solomon AS., Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system. Exp Neurol 2009;218(1):24-32. Stein D, Neufeld A, Pasternak O, Graif M, Patish H, Schwimmer E, Ziv E, Assaf Y., Diffusion tensor imaging of the median nerve in healthy and carpal tunnel syndrome subjects. J Magn Reson Imaging 2009;29(3):657-662. Mezer A, Yovel Y, Pasternak O, Gorfine T, Assaf Y., Cluster analysis of resting-state fMRI time series. Neuroimage 2009;45(4):1117-1125. Assaf Y., Can we use diffusion MRI as a bio-marker of neurodegenerative processes?Bioessays 2008;30(11-12):1235-1245. Avram L, Ozarslan E, Assaf Y, Bar-Shir A, Cohen Y, Basser PJ., Three-dimensional water diffusion in impermeable cylindrical tubes: theory versus experiments. NMR Biomed 2008;21(8):888-898. Pasternak O, Assaf Y, Intrator N, Sochen N., Variational multiple-tensor fitting of fiber-ambiguous diffusion-weighted magnetic resonance imaging voxels. Magn Reson Imaging 2008;26(8):1133-1144.2009;22(7):716-729. Assaf Y, Blumenfeld-Katzir T, Yovel Y, Basser PJ., AxCaliber: a method for measuring axon diameter distribution from diffusion MRI. Magn Reson Med 2008;59(6):1347-1354. Tsenter J, Beni-Adani L, Assaf Y, Alexandrovich AG, Trembovler V, Shohami E., Dynamic changes in the recovery after traumatic brain injury in mice: effect of injury severity on T2-weighted MRI abnormalities, and motor and cognitive functions. J Neurotrauma 2008;25(4):324-333. Assaf Y, Pasternak O., Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review. J Mol Neurosci 2008;34(1):51-61. Assaf Y, Galron R, Shapira I, Nitzan A, Blumenfeld-Katzir T, Solomon AS, Holdengreber V, Wang ZQ, Shiloh Y, Barzilai A., MRI evidence of white matter damage in a mouse model of Nijmegen breakage syndrome. Exp Neurol 2008;209(1):181-191. Komlosh ME, Horkay F, Freidlin RZ, Nevo U, Assaf Y, Basser PJ., Detection of microscopic anisotropy in gray matter and in a novel tissue phantom using double Pulsed Gradient Spin Echo MR. J Magn Reson 2007;189(1):38-45. Mayzel-Oreg O, Assaf Y, Gigi A, Ben-Bashat D, Verchovsky R, Mordohovitch M, Graif M, Hendler T, Korczyn A, Cohen Y., High b-value diffusion imaging of dementia: application to vascular dementia and alzheimer disease. J Neurol Sci 2007;257(1-2):105-113. Yovel Y, Assaf Y., Virtual definition of neuronal tissue by cluster analysis of multi-parametric imaging (virtual-dot-com imaging). Neuroimage 2007;35(1):58-69. Assaf Y, Ben-Sira L, Constantini S, Chang LC, Beni-Adani L., Diffusion tensor imaging in hydrocephalus: initial experience. AJNR Am J Neuroradiol 2006;27(8):1717-1724. Mendelsohn A, Strous RD, Bleich M, Assaf Y, Hendler T., Regional axonal abnormalities in first episode schizophrenia: preliminary evidence based on high b-value diffusion-weighted imaging. Psychiatry Res 2006;146(3):223-229. Gorfine T, Assaf Y, Goshen-Gottstein Y, Yeshurun Y, Zisapel N., Sleep-anticipating effects of melatonin in the human brain. Neuroimage 2006;31(1):410-418. Schonberg T, Pianka P, Hendler T, Pasternak O, Assaf Y., Characterization of displaced white matter by brain tumors using combined DTI and fMRI. Neuroimage 2006;30(4):1100-1111. Neufeld A, Assaf Y, Graif M, Hendler T, Navon G., Susceptibility-matched envelope for the correction of EPI artifacts. Magn Reson Imaging 2005;23(9):947-951. Assaf Y, Chapman J, Ben-Bashat D, Hendler T, Segev Y, Korczyn AD, Graif M, Cohen Y. White matter changes in multiple sclerosis: correlation of q-space diffusion MRI and 1H MRS. Magn Reson Imaging 2005;23(6):703-710. Biton IE, Mayk A, Kidron D, Assaf Y, Cohen Y. Improved detectability of experimental allergic encephalomyelitis in excised swine spinal cords by high b-value q-space DWI. Exp Neurol 2005;195(2):437-446. Assaf Y, Basser PJ. Composite hindered and restricted model of diffusion (CHARMED) MR imaging of the human brain. Neuroimage 2005;27(1):48-58. Meshorer E, Biton IE, Ben-Shaul Y, Ben-Ari S, Assaf Y, Soreq H, Cohen Y. Chronic cholinergic imbalances promote brain diffusion and transport abnormalities. FASEB J 2005;19(8):910-922. Ben Bashat D, Ben Sira L, Graif M, Pianka P, Hendler T, Cohen Y, Assaf Y. Normal white matter development from infancy to adulthood: comparing diffusion tensor and high b value diffusion weighted MR images. J Magn Reson Imaging 2005;21(5):503-511. Assaf Y, Freidlin RZ, Rohde GK, Basser PJ., New modeling and experimental framework to characterize hindered and restricted water diffusion in brain white matter. Magn Reson Med 2004;52(5):965-978. Avram L, Assaf Y, Cohen Y., The effect of rotational angle and experimental parameters on the diffraction patterns and micro-structural information obtained from q-space diffusion NMR: implication for diffusion in white matter fibers. J Magn Reson 2004;169(1):30-38. Biton IE, Mayk A, Assaf Y, Cohen Y., Structural changes in glutamate cell swelling followed by multiparametric q-space diffusion MR of excised rat spinal cord. Magn Reson Imaging 2004;22(5):661-672. Assaf Y, Pianka P, Rotshtein P, Sigal M, Hendler T., Deviation of Fiber Tracts in the Vicinity of Brain Lesions: Evaluation by Diffusion Tensor Imaging. Isr J Chem 2003;43:155-163. Assaf Y, Mayk A, Eliash S, Speiser Z, Cohen Y., Hypertension and neuronal degeneration in excised rat spinal cord studied by high-b value q-space diffusion magnetic resonance imaging. Exp Neurol 2003;184(2):726-736. Hendler T, Pianka P, Sigal M, Kafri M, Ben-Bashat D, Constantini S, Graif M, Fried I, Assaf Y., Delineating gray and white matter involvement in brain lesions: three-dimensional alignment of functional magnetic resonance and diffusion-tensor imaging. J Neurosurg 2003;99(6):1018-1027. Cohen Y, Assaf Y., High b-value q-space analyzed diffusion-weighted MRS and MRI in neuronal tissues – a technical review. NMR Biomed 2002;15(7-8):516-542. Assaf Y, Mayzel-Oreg O, Gigi A, Ben-Bashat D, Mordohovitch M, Verchovsky R, Reider G, II, Hendler T, Graif M, Cohen Y, Korczyn AD., High b value q-space-analyzed diffusion MRI in vascular dementia: a preliminary study. J Neurol Sci 2002;203-204:235-239. Assaf Y, Kafri M, Shinar H, Chapman J, Korczyn AD, Navon G, Cohen Y., Changes in axonal morphology in experimental autoimmune neuritis as studied by high b-value q-space (1)H and (2)H DQF diffusion magnetic resonance spectroscopy. Magn Reson Med 2002;48(1):71-81. Assaf Y, Ben-Bashat D, Chapman J, Peled S, Biton IE, Kafri M, Segev Y, Hendler T, Korczyn AD, Graif M, Cohen Y., High b-value q-space analyzed diffusion-weighted MRI: application to multiple sclerosis. Magn Reson Med 2002;47(1):115-126. Beni-Adani L, Gozes I, Cohen Y, Assaf Y, Steingart RA, Brenneman DE, Eizenberg O, Trembolver V, Shohami E., A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice. J Pharmacol Exp Ther 2001;296(1):57-63. Assaf Y, Mayk A, Cohen Y., Displacement imaging of spinal cord using q-space diffusion-weighted MRI. Magn Reson Med 2000;44(5):713-722. Assaf Y, Cohen Y., Assignment of the water slow-diffusing component in the central nervous system using q-space diffusion MRS: implications for fiber tract imaging. Magn Reson Med 2000;43(2):191-199. Assaf Y, Holokovsky A, Berman E, Shapira Y, Shohami E, Cohen Y., Diffusion and perfusion magnetic resonance imaging following closed head injury in rats. J Neurotrauma 1999;16(12):1165-1176. Assaf Y, Cohen Y., Structural information in neuronal tissue as revealed by q-space diffusion NMR spectroscopy of metabolites in bovine optic nerve. NMR Biomed 1999;12(6):335-344. Assaf Y, Cohen Y., In vivo and in vitro bi-exponential diffusion of N-acetyl aspartate (NAA) in rat brain: a potential structural probe? NMR Biomed 1998;11(2):67-74. Assaf Y, Cohen Y., Non-mono-exponential attenuation of water and N-acetyl aspartate signals due to diffusion in brain tissue. J Magn Reson 1998;131(1):69-85. Assaf Y, Navon G, Cohen Y., In vivo observation of anisotropic motion of brain water using 2H double quantum filtered NMR spectroscopy. Magn Reson Med 1997;37(2):197-203. Assaf Y, Beit-Yannai E, Shohami E, Berman E, Cohen Y. Diffusion- and T2-weighted MRI of closed-head injury in rats: a time course study and correlation with histology. Magn Reson Imaging 1997;15(1):77-85. Assaf Y, Cohen Y. Detection of different water populations in brain tissue using 2H single- and double-quantum-filtered diffusion NMR spectroscopy. J Magn Reson B 1996;112(2):151-159.
bottom of page